Unraveling the long sought-after vitamin K reducing enzyme FSP1 Eikan Mishima, first author of the study explained. "Surprisingly, we identified that vitamin K, including phylloquinone (vitamin K1) and menaquinone-4 (vitamin K2), is able to efficiently rescue cells and tissues from undergoing ferroptosis" Dr. Marcus Conrad, both from the Institute of Metabolism and Cell Death at Helmholtz Munich, along with collaborators from Tohoku University (Japan), University of Ottawa (Canada) and Technical University of Dresden (Germany), systematically studied a number of naturally occurring vitamins, as well as their derivatives. To identify these new molecules, a team of researchers led by Dr. Since ferroptosis prevention is considered a highly promising approach for the therapy of many degenerative diseases, new mechanisms and compounds regulating ferroptosis are extensively being explored. Vitamin K is a potent ferroptosis suppressor Thus, the present findings put forward the concept that vitamin K treatment might be a new powerful strategy to ameliorate these ferroptosis-related diseases. During the last years, ferroptosis has been implicated as a driver of Alzheimer's disease and acute organ injuries among many other diseases.
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